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KMID : 0438219750120010263
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Korea University Medical Journal
1975 Volume.12 No. 1 p.263 ~ p.276
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An Experimental Study on the Effects of Roentgen Irradiation Upon the Liver of the Rabbit
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Abstract
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Until recently, the liver was considered to be resistant to ionizing radiation, and the reports concerning the results of irradiation to the liver in animal and human have mainly dealt with the late effects.
Therefore, the author made an experiment to elucidate more clearly the early changes in serum enzymes and histopathology of rabbit´s liver following irradiation to the liver, lower abdomon and both legs respectively.
All animals were equally divided into 7 groups and exposed to various single or fractionated doses of x ray.
Of the 70 animals studied, 10 were normal control group (Group A) ; 10 received a single dose of 500 R over the lower abdomen (Group B) ; 10 received a single dose of 50O R to both legs (Group C) ; 10 received a single dose of 500 R to the liver (Group D) ; 10 received a single dose of 1, 000 R to the liver (Group E); 10 received 1,000R to the liver in 5 fractionated doses(Group F) and 10 received a total dose of 4, 000 R to the liver in 20 fractionated doses over a period of 4 weeks (Group G).
Blood samples for enzyme and histologic changes were observed after 2 weeks following the day of the last irradiation.
The results obtained are as follows:
1. In the groups received a single dose of 500 R to 1, 000 R to the liver, there were minimal changes in hepatic parenchymal cells, blood vessels and portal interstitium at 2 weeks, and these changes were slightly more prominent at 3 weeks.
2. In the group received 4, 000 R to the liver with fractionated irradiation, necrosis and fibrosis of moderate degree were found in the portal interstitium, and there were also moderately damaged hepatic parenchymal cells, blood vessels and portal interstitium. But Kupffer cells revealed only slight morphological change.
3. Among the tissues of the liver, the central veins were most easily and markedly affected by radiation.
4. Even in the group received a single dose of 500 R to both legs or over the lower abdomen with the liver shielded, the hepatic parenchymal cells were found to be slightly damaged. This might be
attributed to an indirect hepatotoxic effect of some toxic material produced in the irradiated tissues other than the liver.
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